While Derm Exclusive claims that their products are clinically proven, there are no studies referenced on their website. Based on the company’s description, user can expect to see immediate results with Fill & Freeze, while the complementary products will provide noticeable results within 14 days, and “dramatic results” within 4-6 weeks. Since it contains one powerful ingredient Argireline, most users should be able to see quick results, but with repeated applications, this product is NOT much of a long term collagen and skin builder. We recommend LifeCell over Fill and Freeze anti aging regimen. LifeCell also has Argireline as well as other powerful collagen building compounds and peptides like DMAE etc.